diff --git a/man/tio.1.in b/man/tio.1.in
index 0576d0d..97ef873 100644
--- a/man/tio.1.in
+++ b/man/tio.1.in
@@ -417,7 +417,7 @@ Enable hexadecimal mode
 .IP "\fBsocket"
 Set socket to redirect I/O to
 .IP "\fBprefix-ctrl-key"
-Set prefix ctrl key (a..z, default: t)
+Set prefix ctrl key (a..z or 'none', default: t)
 .IP "\fBresponse-wait"
 Enable wait for line response
 .IP "\fBresponse-timeout"
diff --git a/src/configfile.c b/src/configfile.c
index 387063b..ef97f31 100644
--- a/src/configfile.c
+++ b/src/configfile.c
@@ -259,7 +259,11 @@ static int data_handler(void *user, const char *section, const char *name,
         }
         else if (!strcmp(name, "prefix-ctrl-key"))
         {
-            if (ctrl_key_code(value[0]) > 0)
+            if (!strcmp(value, "none"))
+            {
+                option.prefix_enabled = false;
+            }
+            else if (ctrl_key_code(value[0]) > 0)
             {
                 option.prefix_code = ctrl_key_code(value[0]);
                 option.prefix_key = value[0];
diff --git a/src/options.c b/src/options.c
index 4f08e6d..8cfede9 100644
--- a/src/options.c
+++ b/src/options.c
@@ -86,6 +86,7 @@ struct option_t option =
     .hex_mode = false,
     .prefix_code = 20, // ctrl-t
     .prefix_key = 't',
+    .prefix_enabled = true,
     .response_wait = false,
     .response_timeout = 100,
     .mute = false,
diff --git a/src/options.h b/src/options.h
index b18d8ff..f1f2f73 100644
--- a/src/options.h
+++ b/src/options.h
@@ -59,6 +59,7 @@ struct option_t
     bool hex_mode;
     unsigned char prefix_code;
     unsigned char prefix_key;
+    bool prefix_enabled;
     bool response_wait;
     int response_timeout;
     bool mute;
diff --git a/src/tty.c b/src/tty.c
index e620f8f..abf79e9 100644
--- a/src/tty.c
+++ b/src/tty.c
@@ -339,7 +339,7 @@ void *tty_stdin_input_thread(void *arg)
 
                 input_char = input_buffer[i];
 
-                if (previous_char == option.prefix_code)
+                if (option.prefix_enabled && previous_char == option.prefix_code)
                 {
                     if (input_char == option.prefix_code)
                     {
@@ -569,7 +569,7 @@ void handle_command_sequence(char input_char, char *output_char, bool *forward)
     }
 
     /* Handle escape key commands */
-    if (previous_char == option.prefix_code)
+    if (option.prefix_enabled && previous_char == option.prefix_code)
     {
         /* Do not forward input char to output by default */
         *forward = false;
@@ -1545,7 +1545,7 @@ int tty_connect(void)
                     if (interactive_mode)
                     {
                         /* Do not forward prefix key */
-                        if (input_char == option.prefix_code)
+                        if (option.prefix_enabled && input_char == option.prefix_code)
                         {
                             forward = false;
                         }