diff --git a/meson.build b/meson.build
index 1ed5d9a..b5bbca6 100644
--- a/meson.build
+++ b/meson.build
@@ -11,8 +11,15 @@ version_date = '2022-02-15'
 # Test for dynamic baudrate configuration interface
 compiler = meson.get_compiler('c')
 enable_setspeed2 = false
-if compiler.check_header('asm-generic/ioctls.h')
-  enable_setspeed2 = compiler.has_header_symbol('asm-generic/ioctls.h', 'TCGETS2')
+enable_iossiospeed = false
+if host_machine.system() != 'darwin'
+  if compiler.check_header('asm-generic/ioctls.h')
+    enable_setspeed2 = compiler.has_header_symbol('asm-generic/ioctls.h', 'TCGETS2')
+  endif
+else
+  if compiler.check_header('IOKit/serial/ioss.h')
+    enable_iossiospeed = compiler.has_header_symbol('IOKit/serial/ioss.h', 'IOSSIOSPEED')
+  endif
 endif
 
 # Test for supported baudrates
diff --git a/src/iossiospeed.c b/src/iossiospeed.c
new file mode 100644
index 0000000..3b0c62f
--- /dev/null
+++ b/src/iossiospeed.c
@@ -0,0 +1,28 @@
+/*
+ * tio - a simple TTY terminal I/O application
+ *
+ * Copyright (c) 2017  Martin Lund
+ *
+ * This program is free software; you can redistribute it and/or
+ * modify it under the terms of the GNU General Public License
+ * as published by the Free Software Foundation; either version 2
+ * of the License, or (at your option) any later version.
+ *
+ * This program is distributed in the hope that it will be useful,
+ * but WITHOUT ANY WARRANTY; without even the implied warranty of
+ * MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the
+ * GNU General Public License for more details.
+ *
+ * You should have received a copy of the GNU General Public License
+ * along with this program; if not, write to the Free Software
+ * Foundation, Inc., 51 Franklin Street, Fifth Floor, Boston, MA
+ * 02110-1301, USA.
+ */
+
+#include <sys/ioctl.h>
+#include <IOKit/serial/ioss.h>
+
+int iossiospeed(int fd, int baudrate)
+{
+  return ioctl(fd, IOSSIOSPEED, (char *)&baudrate);
+}
diff --git a/src/meson.build b/src/meson.build
index a1d5502..6aed1fc 100644
--- a/src/meson.build
+++ b/src/meson.build
@@ -20,6 +20,11 @@ if enable_setspeed2
   tio_c_args += '-DHAVE_TERMIOS2'
 endif
 
+if enable_iossiospeed
+  tio_sources += 'iossiospeed.c'
+  tio_c_args += '-DHAVE_IOSSIOSPEED'
+endif
+
 executable('tio',
   tio_sources,
   c_args: tio_c_args,
diff --git a/src/tty.c b/src/tty.c
index 64098b4..5cec626 100644
--- a/src/tty.c
+++ b/src/tty.c
@@ -49,6 +49,10 @@
 extern int setspeed2(int fd, int baudrate);
 #endif
 
+#ifdef HAVE_IOSSIOSPEED
+extern int iossiospeed(int fd, int baudrate);
+#endif
+
 #ifdef __APPLE__
 #define PATH_SERIAL_DEVICES "/dev/"
 #else
@@ -347,7 +351,7 @@ void tty_configure(void)
         BAUDRATE_CASES
 
         default:
-#ifdef HAVE_TERMIOS2
+#if defined (HAVE_TERMIOS2) || defined (HAVE_IOSSIOSPEED)
             standard_baudrate = false;
             break;
 #else
@@ -647,6 +651,15 @@ int tty_connect(void)
     if (tcgetattr(fd, &tio_old) < 0)
         goto error_tcgetattr;
 
+#ifdef HAVE_IOSSIOSPEED
+    if (!standard_baudrate)
+    {
+        /* OS X wants these fields left alone. We'll set baudrate with iossiospeed below. */
+        tio.c_ispeed = tio_old.c_ispeed;
+        tio.c_ospeed = tio_old.c_ospeed;
+    }
+#endif
+
     /* Make sure we restore tty settings on exit */
     if (first)
     {
@@ -668,7 +681,18 @@ int tty_connect(void)
         if (setspeed2(fd, option.baudrate) != 0)
         {
             error_printf_silent("Could not set baudrate speed (%s)", strerror(errno));
-            goto error_setspeed2;
+            goto error_setspeed;
+        }
+    }
+#endif
+
+#ifdef HAVE_IOSSIOSPEED
+    if (!standard_baudrate)
+    {
+        if (iossiospeed(fd, option.baudrate) != 0)
+        {
+            error_printf_silent("Could not set baudrate speed (%s)", strerror(errno));
+            goto error_setspeed;
         }
     }
 #endif
@@ -815,8 +839,8 @@ int tty_connect(void)
 
     return TIO_SUCCESS;
 
-#ifdef HAVE_TERMIOS2
-error_setspeed2:
+#if defined (HAVE_TERMIOS2) || defined (HAVE_IOSSIOSPEED)
+error_setspeed:
 #endif
 error_tcsetattr:
 error_tcgetattr: